Vaccination against Covid-19 should be based on scientific evidence. The article suggests that vaccines should be approved mainly for at-risk groups under the age of 65. Every year, a prospective placebo-controlled study should be conducted in healthy people aged 50–64 years. Retrospective studies from 2022–2025 showed that mRNA vaccines against Covid-19 are effective in all age groups, regardless of risk factors, at least several months after vaccination. Vaccines have been administered to hundreds of millions of people and their safety is confirmed by large studies. A study with more than 100 million participants confirmed that vaccines are very safe. Small studies designed for healthy adults aged 50–64 are unlikely to yield important new information on efficacy or safety.