In patients with acute myocardial infarction and multiple involvement of coronary vessels, complete revascularization significantly reduces the risk of cardiovascular death and new myocardial infarction compared with revascularization focused only on the culprit (culprit lesion). In addition, complete revascularization reduces overall mortality. A meta-analysis of individual data from randomized trials provides the strongest evidence that this strategy improves important clinical outcomes in these patients. The results show that complete revascularization reduces the combined incidence of cardiovascular death or new myocardial infarction, as well as cardiovascular death alone. All-cause mortality was also lower in the complete revascularization group. These findings support the use of a comprehensive approach in the treatment of patients with acute myocardial infarction and multiple coronary artery involvement[1].