Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction

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Source: NEJM

Original: https://www.nejm.org/doi/full/10.1056/NEJMoa2512686?af=R&rss=currentIssue...

Published: 2025-11-09T04:09:00Z

Beta-blockers are standardly used after a myocardial infarction, especially with a reduced ejection fraction. The study investigated whether beta-blockers also have an advantage in patients with a normal ejection fraction after a heart attack. The study included patients with acute myocardial infarction and normal left ventricular ejection fraction. The results showed that beta-blockers did not reduce the incidence of major cardiovascular events in these patients compared to the control group. The study did not confirm a significant beneficial effect of beta-blockers on overall mortality or hospitalization for heart disease in patients with a normal ejection fraction. The results suggest that the efficacy of beta-blockers after a heart attack may be limited in patients with impaired systolic heart function.