The World Health Organization (WHO) has announced that Egypt has become the seventh country in the Eastern Mediterranean region to eliminate trachoma as a public health problem, bringing the number of such countries globally to 27. Trachoma, caused by the bacterium Chlamydia trachomatis, has been documented in Egypt for more than 3,000 years and is spread by contact with infected ocular discharges through hands, clothing, surfaces or flies. Since 2002, the Egyptian Ministry of Health, in collaboration with WHO, has applied the SAFE strategy: surgical interventions against trichiasis, antibiotics, facial cleanliness and environmental improvement. Between 2015 and 2025, extensive mapping in 27 governorates showed a decline in the active form of the disease in children aged 1-9 years below the WHO threshold and no significant blinding complications in adults. In 2024, Egypt integrated trachoma surveillance into the national electronic disease reporting system. This is the second neglected tropical disease eliminated in Egypt after lymphatic filariasis in 2018. Trachoma remains a problem in 30 countries, where it threatens 103 million people in endemic areas and causes blindness or visual impairment in 1.9 million people. Success has been achieved through national leadership, partnerships with WHO and organisations such as Haya Karima and Sightsavers.