Acute kidney injury (AKI) is a frequent organ failure in the hospital environment that can significantly worsen the patient's short-term and long-term health status. Pharmacological treatment of AKI is still insufficient, therefore emphasis is placed on supportive measures that can reduce the incidence and severity of this condition. Bundled interventions, especially in the perioperative period, where preventive measures can be better timed, show promising results in the prevention of AKI. Early diagnosis, stratification of risk patients and management according to the cause of damage are key. Administration of balanced crystalloids instead of colloids, avoidance of diuretics to prevent AKI, and avoidance of low-dose dopamine as treatment are recommended. Protocols aimed at maintaining hemodynamic and oxygenation parameters in at-risk patients may prevent the development of AKI. Overall, promoting care without drug interventions is important for improving outcomes in patients with AKI[1].