Analgesia in the pre-hospital environment is a demanding priority for paramedics. Retrospective military data show an association between early morphine analgesia after injury and a lower risk of long-term sequelae such as post-traumatic stress disorder. However, the proportion of patients with pain who receive analgesia in the pre-hospital setting is low. This low proportion may be related to difficulties in obtaining intravenous access. Another reason is concern about the hemodynamic effects and many side effects of opioids. Methoxyflurane has been reported as a promising non-intravenous, non-opioid analgesic.