This article is a correction to the original study on the neuroprotective role of Sirt1 protein in mammalian models of Huntington's disease. Sirt1 acts through a protective mechanism by activating several target molecules that are important for the survival of neurons affected by the disease. Research confirms that increased Sirt1 activity improves brain function and slows the progression of Huntington's disease in experimental models. The study highlights the importance of multiple Sirt1 targets that together contribute to its neuroprotective effect. A correction is made to clarify some details in the original text that do not affect the main conclusions. The results support the possibility of using Sirt1 as a therapeutic target in the treatment of Huntington's disease. The article was published in the journal Nature Medicine on November 26, 2025.