A new high-speed "turn-on-and-freeze" imaging method has allowed scientists to observe in detail how brain cells communicate via synaptic vesicles in neurons in both mice and humans. By freezing the tissue at the moment the signal is triggered, they have been able to reveal the mechanisms of message transmission in the brain that may explain why most cases of Parkinson's disease arise without inherited genetic changes. This breakthrough provides the clearest insight into the cellular processes associated with Parkinson's disease. The new technique also opens up new avenues for research and development of treatments for this neurodegenerative disease. Parkinson's disease is characterised by motor impairments such as tremors, muscle stiffness and slowed movements, which are now treated with treatments such as deep brain stimulation. This imaging method can help to better understand the underlying causes of the disease and lead to new therapeutic approaches. The research is particularly important because Parkinson's disease does not yet have a cure and its causes are not yet fully understood.