Advances in antiretroviral therapy since 1988 have fundamentally changed the treatment and prevention of HIV/AIDS. In 2024, more than 40 million people were living with HIV, with 1.3 million new infections and 660,000 deaths. The latest therapeutic developments offer hope for ending the epidemic, but this requires expanding access to treatment and prevention. Particularly vulnerable groups such as adolescent girls and young women (210,000 new infections in 2024) and key populations have a higher proportion of new cases. Programs like PEPFAR and the Global Fund are critical to providing medicines and diagnostics, but their funding remains uncertain. Continued cuts in financial aid could lead to thousands more deaths and millions of new infections. To stop the pandemic, international support needs to be renewed and increased and all stakeholders must be involved.