The study aimed to develop a nomogram to predict weaning-induced pulmonary edema (WIPE) in patients with cardiogenic respiratory failure on mechanical ventilation. 262 patients treated between April 2021 and December 2023 were retrospectively analyzed. Identified independent risk factors for WIPE included history of hypertension, APACHE II score, NYHA cardiac function grade, RSBI, duration of mechanical ventilation, left ventricular diastolic dysfunction, and presence of COPD. The logistic regression model achieved high predictive accuracy with an AUC of 0.884, a sensitivity of 92.3% and a specificity of 81.1%. The calibration curve confirmed a good agreement between the predicted and real results (MAE = 0.050). This model may help clinicians to identify patients at high risk of WIPE early, but external validation in larger multicenter studies is needed before its clinical use.