A study investigated the diagnostic and prognostic value of antithrombin III (AT-III) activity in sepsis-induced coagulopathy (SIC) in 366 septic patients, of whom 235 (64.2%) had SIC and 131 (35.8%) did not have SIC.[1] AT-III activity was significantly lower in the SIC group than in the non-SIC group (P < 0.001).[1] ROC curve analysis showed that the area under the curve (AUC) for AT-III activity was 0.799, which was comparable to traditional diagnostic markers such as platelets (AUC 0.806), SOFA score (AUC 0.746), and internationally normalized ratio (AUC 0.751).[1] The cut-off value of AT-III activity for the diagnosis of SIC was 59.7% with a sensitivity of 79.91% and a specificity of 69.77%.[1] Patients with high AT-III activity (≥ 59.7%) had a lower rate of shock and shorter duration of vasopressor use compared to patients with low AT-III activity (< 59.7%).[1] However, there was no statistically significant difference in the 28-day survival rate between the high and low AT-III groups (P = 0.350).[1] The study concluded that AT-III activity is a potentially useful adjunctive biomarker for the diagnosis of SIC that functions similarly to biomarkers and scores currently used for the diagnosis of SIC.[1]