This article from the December 4, 2025 issue of JAMA (Journal of the American Medical Association) covers a variety of medical topics. Highlights include a discussion of real-world evidence for Medicare drug price negotiations. The article also contains information for patients about ovarian cancer. It also deals with an overview of hemorrhoidal disease and the diagnosis and treatment of peripheral neuropathy. The therapeutic use of cannabis and cannabinoids in MASLD (metabolic dysfunction associated with hepatic steatosis) and keratocyte health are also mentioned. The article also draws attention to the World Health Organization (WHO) guideline on glucagon-like peptide-1 therapies for the treatment of obesity.