A systematic review and meta-analysis investigated the efficacy and safety of endoscopic surgery combined with platelet-rich plasma (PRP) in the treatment of lumbar disc herniation. The analysis included 12 studies with a total of 960 patients and showed a significant reduction in back and leg pain at all time points, with the greatest improvement at 3 months. Functionality and quality of life scores of patients improved significantly according to the Japanese Orthopedic Scale and the Oswestry Disability Index. The combined treatment also led to an increase in the height of the intervertebral disc and a reduction in the number of recurrences (to 27% of the original value). The incidence of complications was not statistically different between the treatment and control groups. Despite the positive results, the authors emphasize the need for more qualitative research with better methodology to definitively confirm the effectiveness and safety of this combined treatment.