Follicular lymphoma is described in the article as an incurable tumor disease, for which the repeated return (recurrence) of the disease is typical. Although patients often respond well to first-line treatment, most relapse over time. Lymphoma itself or complications related to treatment remain the leading cause of death in patients with this disease. Evidence shows that the duration of response to treatment decreases with each additional line of therapy. With each subsequent line of treatment, progression-free survival gradually worsens. In the same way, after each additional line of treatment, the overall survival of patients is also shortened.