Chronic hepatitis E virus (HEV) infection is a significant cause of post-transplant hepatitis in kidney transplant patients. The study followed two kidney transplant recipients diagnosed with chronic HEV infection without obvious clinical symptomatology but with abnormal liver function tests. Viral sequences identified in patient stool belonged to HEV-3c and HEV-3ra subtypes, HEV-3ra being the zoonotic variant associated with rabbits and the first reported case of this subtype in transplant patients. Immunosuppressive therapy alone was not sufficient to eradicate the virus, but after six months of treatment with the antiviral ribavirin, both patients achieved a sustained virological response. The results highlight the need for systematic HEV surveillance and molecular diagnostics in transplant patients to start antiviral therapy early and prevent liver disease progression. This study expands knowledge about chronic hepatitis E in kidney transplant patients, especially in relation to the new HEV-3ra subtype.