The new imaging technique ComSLI (Computational Scattered Light Imaging) enables detailed imaging of the orientation of microscopic nerve fibers in the brain with micrometer accuracy. This method uses a rotating LED light and a simple microscopic device to capture scattered light, which reveals the direction and course of fibers in various types of tissue preparations, including fresh and more than a century old samples. ComSLI is independent of the method of sample preparation, which expands the possibilities of analysis of existing tissue sections. Using this technique, researchers were able to identify microstructural changes related to neurological diseases such as Alzheimer's disease, multiple sclerosis or leukoencephalopathy. In addition to the brain, ComSLI can also be used to study the architecture of muscles, bones and blood vessels. This method represents a significant advance for neuroscience and biomedical research, and was published in the prestigious journal Nature Communications. ComSLI thus offers new possibilities for diagnosis and detailed mapping of neural networks on a microscopic scale[1].