A patient with granular corneal dystrophy type 2 (GCD2) experienced significant worsening of the disease and progressive vision loss after LASIK laser surgery. Examination of the anterior segment of the eye showed extensive granular opacities in the cornea, especially in the area of the LASIK lobe interface. Genetic analysis revealed the presence of the heterozygous c.371G > A mutation in the TGFBI gene, which causes the R124H substitution and is inherited in an autosomal dominant manner, in the patient and 14 of the 37 tested family members. The results confirm that LASIK surgery significantly accelerates the progression of GCD2 through several pathophysiological mechanisms. The authors emphasize the necessity of a comprehensive preoperative examination, including genetic screening for TGFBI mutations, to identify patients in whom LASIK is contraindicated. Granular corneal dystrophy type 2 is a genetically determined disease that is manifested by a gradual deterioration of vision in childhood or young age. This case highlights the risk of refractive surgery in patients with this mutation and the need for preoperative genetic testing.