Brief, factual summary in Slovak: The new edition of the journal JAMA contains information about two important clinical studies. The first is ANDROMEDA-SHOCK-2, a randomized clinical trial focused on personalized hemodynamic resuscitation targeting capillary return in septic shock. The second is a review article on superficial venous thrombosis. Also included in this issue are editorials, commentaries, and other articles on critically ill patients, acute kidney injury, and other topics. Overall, this edition provides physicians worldwide with important medical information and a unique forum to discuss the future of medical practice and public health.