Complex regional pain syndrome (CRPS) is a chronic neuropathic pain condition that often develops after injury or immobilization of a limb. It is characterized by intense, persistent pain that is disproportionate to the severity of the original damage, accompanied by increased sensitivity (hyperalgesia, allodynia), motor disorders, changes in vascular supply and sweating, as well as trophic changes in the skin and tissues[1][2]. The pain is often "burning" or "electrical" in nature, which can change to dull or stabbing, and is aggravated by movement, touch or changes in temperature[1]. Motor symptoms are very common and include weakness, tremors, muscle spasms, dystonia and limited mobility, with motor dysfunction reported in up to 97% of affected limbs[1]. Pathophysiologically, a combination of peripheral and central neuroinflammation is assumed, leading to sensitization of the nervous system and extension of symptoms[1][2]. CRPS is divided into several subtypes according to the predominant symptoms: inflammatory, neuropathic, vasomotor and motor, which allows for more targeted treatment[2]. Diagnostic criteria include the presence of persistent pain and at least three of the following symptom categories: sensory, vasomotor, sudomotor/edematous, and motor/trophic[2][3]. Rating scales such as the CRPS Severity Score (CSS) help monitor the severity and course of the disease[3].