Scientists from the Italian team conducted a network meta-analysis of 76 randomized controlled trials with 17,379 participants, which showed that the best way to stop antidepressants is a slow dose reduction combined with psychological support[1]. This approach reduces the risk of depression relapse to a level similar to continuation of treatment and is significantly more effective than rapid or abrupt discontinuation of medication[1]. The majority of patients were taking SSRIs or SNRIs, the average age was 45 years, and 68% were women[1]. Antidepressant withdrawal syndrome occurs in approximately 15% of patients, but is often confused with disease relapse[1][2]. Withdrawal symptoms usually appear 2–4 days after abruptly stopping treatment and may include dizziness, sweating, nausea, or vomiting[2][10]. Gradual tapering of medication is therefore recommended to minimize the risk of withdrawal symptoms and relapse[2][4][6]. Psychological support during drug withdrawal helps manage possible symptoms and reduces the likelihood of depression returning[1][2]. Sudden discontinuation of antidepressants can lead to the so-called FINISH syndrome, which includes various physical and psychological symptoms[4]. Overall, slow and controlled withdrawal in combination with therapy is considered the safest and most effective way to end antidepressant treatment[1][2][6].