The article presents a rare case of cryptococcal pericarditis with unexplained multiple lymphadenopathy in a 40-year-old immunocompetent man without underlying diseases or risk behaviors. The patient had a chronic cough with sputum production, imaging revealed bilateral lung lesions, widespread lymphadenopathy, and pericardial effusion. Tests for cryptococcal antigen were positive in serum and pericardial fluid, HIV test was negative and immunological examination was normal. 585 ml of effusion was removed by pericardiocentesis. Treatment included intravenous fluconazole 0.4 g daily for 1 week, then oral for 4 months. Two weeks after discharge, echocardiography did not reveal a significant effusion, at 4 months there was a small residual effusion, cough and sputum improved. The patient maintained normal physical activity without restrictions. The report emphasizes that fungal infection should be considered even in immunocompetent patients with pericarditis.