A retrospective study evaluated compression suture of uterine mesh in 45 patients with refractory postpartum hemorrhage. Active uterine bleeding was controlled within 10 minutes after surgery in all, and the cumulative volume of vaginal bleeding 2 hours after the procedure was less than 20 ml. Postoperative day 4 MRI showed scattered punctate signals in the uterine wall without intrauterine fluid accumulation. After 42 days, MRI showed a uniform signal in the myometrium and a clear endometrial line, ultrasound normal size of the uterus with uniform echogenicity and good healing. Hysteroscopy 6 months after surgery did not reveal intrauterine adhesions or a clear fallopian tube opening. All 45 patients resumed normal menstrual cycles 1–2 months after cessation of breastfeeding. Ten patients later became pregnant: 4 underwent repeated caesarean section and 6 artificial abortions. The technique is effective for controlling refractory bleeding unresponsive to traditional methods or blood loss ≥ 1500 mL during caesarean section.