Cutaneous Sarcoidosis with Annular Plaques

Back to news list

Source: NEJM

Original: https://www.nejm.org/doi/full/10.1056/NEJMicm2510745?af=R&rss=currentIssue...

Published: 2025-12-13T12:30:00Z

Cutaneous sarcoidosis in this case was manifested by ring (annular) plaques on the skin, confirmed by clinical examination and histological biopsy showing non-caseous epithelioid granulomas, typical of sarcoidosis[1]. Skin involvement is seen in approximately 25% of patients with sarcoidosis, and skin manifestations can be diverse, including papules, nodules, or patchy infiltrates, as well as lupus pernio[1][2]. The diagnosis in the article was based on a skin biopsy with the correct histopathological finding of granulomas and the exclusion of other granulomatous diseases according to the case description[1]. Systemic involvement was also considered in the evaluation, as sarcoidosis is a systemic disease often affecting the lungs and lymph nodes, although in this report skin lesions were the main finding[2][4]. Treatment with topical or systemic corticosteroids is standard; the initial oral dose often starts in the range of 20–40 mg of prednisone daily, tapering according to response, while topical steroid therapy is indicated for limited skin changes[1]. The author mentions the monitoring of the treatment effect over the course of weeks to months and the need to individualize the treatment regimen depending on the extent and severity of the disease[1][2]. The text presents diagnostic and therapeutic procedures in accordance with the available literature on sarcoidosis, without evidence of another primary disease explaining the granulomatous changes[3].