The study analyzed the burden of family caregivers of critically ill obstetric patients in the ICU of a tertiary care hospital. 150 caregivers randomly selected between January 2023 and December 2024 participated. They used the Zarit Caregiver Burden Interview (ZBI) to measure burden and a demographic questionnaire. The mean ZBI score was 45.15 ± 6.23 points, showing considerable loading. Multivariable regression analysis showed a significant influence of the patient's length of stay in the hospital, age, level of education, monthly family income, social support and psychological resilience of caregivers (P < 0.05). Pearson's correlation showed a negative relationship between burden and social support (r = -0.366, P < 0.001) and psychological resilience (r = -0.307, P = 0.000). The findings highlight the need for interventions to support caregivers with lower social support and psychological resilience.