The British National Formulary (BNF) edition collection documents the growth in content and physical size of this handbook since its first edition in 1949[2][4]. Originally published every three years, since 1976 the frequency of publication has intensified, and since 1981 the BNF has been published every six months, with the cover color changing radically with each issue[1][4]. The increase in the number of new drugs and information has led to an increase in scale, which has motivated the availability of content also in digital form and through the application to cope with the growing volume of data[4]. The BNF evolved from the National War Formulary and was supported from the start by the British Medical Association and the Royal Pharmaceutical Society; since 1949, it has become a key resource for the prescribing and safe use of medicines[2][3]. Since 2005, a separate edition for children (BNFC) has been added, which is published annually[2][4]. The BNF content creation processes are accredited by the NICE organization (the first accreditation was obtained by the BNF in 2016, renewed in 2021)[1][2]. The physical increase in the number of pages and the weight of printed editions has been partially offset by the transition to digital formats and regular semi-annual updates, which allow information to be kept current without the unusual enlargement of a single print.[4][5]