The study describes universal screening for social determinants of health in 2,222 pregnant women in one rural health system in northern New England[1]. 16.7% of those screened mentioned at least one social determinant and 7.8% mentioned two or more determinants[1]. Among patients with only one positive determinant, social isolation was the most frequent (38.9%), followed by financial stress (27.8%)[1]. Among those who had two or more determinants, the most common were financial stress (75.1%), food insecurity (67.6%) and housing instability (56.1%)[1]. The combination of food insecurity, housing instability and financial stress affected almost 10% of female patients[1]. The authors point out that social isolation is a significant problem for pregnant people outside the city with no other reported determinants, while housing insecurity and food insecurity often co-occur with financial stress[1]. The aim of the analysis was to provide baseline data for further research on the relationships between intersecting social determinants and maternal and infant health outcomes and to highlight the importance of universal screening in identifying high-risk patients[1].