A 73-year-old patient with fever and pneumonia, unresponsive to broad-spectrum antibiotics, was diagnosed with severe psittacosis by next-generation metagenomic sequencing (mNGS) from whole blood drawn on day 5 of hospitalization[1]. mNGS detected Chlamydia psittaci DNA with 14 specific sequence reads mapping to the C. psittaci genome[1]. Once the diagnosis was confirmed, oral doxycycline 100 mg every 12 hours was started, which resulted in resolution of fever within 24 hours and normalization of inflammatory markers[1]. Initial conventional serological tests did not identify the pathogen, leading to the use of mNGS to determine the etiology of the infection[1]. The patient denied direct contact with birds, although there were parrots in the household as a potential source of exposure[1]. The authors emphasize that transmission of aerosols from a contaminated environment can lead to infection even without direct contact and that mNGS can help diagnose culture-negative or serologically unexplained pneumonia[1]. This case documents a rapid clinical response to doxycycline in a confirmed C. psittaci infection diagnosed by mNGS[1].