The study examined 116 patients bitten by hemotoxic Trimeresurus and Agkistrodon snakes in Yunnan Province, China, treated at three hospitals. Of these, 33 patients received fibrinogen (Fg) supplementation in addition to standard antivenom (Agkistrodon acutus or Agkistrodon halys antivenom), while 83 patients only received antivenom. Patients with Fg had more severe blood clotting disorders at baseline. In the combined group, PT, INR, TT, APTT, FDP, and D-dimer decreased significantly (all P < 0.05) and Fg level increased (P < 0.05). At discharge, the combined group had a median Fg of 1.94 g/L (1.52–2.20), significantly higher than the 0.84 g/L (0.68–1.17) in the antivenom-only group ( P < 0.0001), closer to the norm of 2–4 g/L. Length of hospital stay was shorter in the combined group (4.88 ± 1.47 days) versus 7.07 ± 2.02 days (P < 0.0001). The findings suggest that Fg supplementation improves coagulation parameters and shortens hospital stay, but further studies are needed.