The World Health Organization (WHO) has confirmed that Brazil has eliminated mother-to-child transmission of HIV, becoming the most populous country in the Americas to achieve this milestone[1][3]. The country has reduced vertical transmission of HIV to below 2% and achieved more than 95% coverage of antenatal care, routine HIV testing and early treatment for pregnant women with HIV[1][3]. Brazil has implemented a progressive subnational approach by certifying states and municipalities with more than 100,000 inhabitants, adapted to the PAHO/WHO methodology[1][3]. Independent experts, with PAHO support, reviewed data, documentation and health facilities, which was endorsed by the WHO Global Advisory Committee[3]. The success is the result of a unified SUS health system, strong primary care and community involvement[1][3]. Between 2015-2024, more than 50,000 childhood HIV infections were prevented in the Americas[1][3]. Brazil is the 19th country in the world with this WHO validation[3].