The article reports a series of significant "runner-up" findings for 2025, scientific results that ranked behind the main "Breakthrough of the Year."[1] Among them is the first use of personalized gene editing in an infant with a life-threatening metabolic disease, suggesting the potential for treating ultra-rare mutations.[1] Another feat described is the discovery that neurons can contribute to the spread of tumors by carrying mitochondria into tumor cells, increasing their ability to metastasize.[1] The article also describes the rapid emergence of large language models (LLMs) in science, including cases where LLMs have made significant advances in mathematics and biological tasks, while highlighting concerns about the quality and misuse of these tools in scientific publishing.[2] It states that LLMs have been used in hypothesis formulation, data analysis, and initial peer review, and some publishers have implemented countermeasures against automated data misuse.The text also includes examples of technological and theoretical advances (e.g., advances in protein structure prediction and revised theoretical predictions in muon experiments) that have impacted several disciplines in 2025.[2