Science Signaling has retracted a 2017 paper that linked a specific form of amyloid (amyloid-beta 56) to tau pathology.The retraction followed an investigation into allegations of data manipulation.The lead author, Sylvain Lesné, PhD, resigned his position for this reason.The paper provided a significant boost to hypotheses about amyloid and toxic oligomers in Alzheimer's disease.[After publication, co-author Karen Ashe was awarded the prestigious Potamkin Prize for her work leading to the discovery of Aβ56.[2] The paper was hailed as a major discovery that influenced the direction of research[2] In an accompanying editorial, the editors of Nature called it a "star suspect" in the pathogenesis of Alzheimer's disease.[2] The paper has been described as a major discovery that has influenced the direction of research.]