Infectious disease experts said the answers to questions about vaccination against respiratory viruses in immunocompromised children and adults are clearer than many doctors think.[original] Live vaccines are contraindicated in immunocompromised patients, including the BCG vaccine, live influenza vaccine, and other live vaccines.1 The immune response to vaccines is often reduced in this group, and there is a risk of spread of live vaccine agents in severely immunocompromised persons.[1] Influenza and pertussis vaccination is recommended for persons in close contact with immunocompromised patients, as are varicella, rotavirus, and pneumococcal vaccines for children in a shared household.In adult hyposplenic or asplenic patients, pneumococcal vaccination includes a single dose of the conjugated vaccine PCV13 followed by the polysaccharide vaccine PPSV23 after a minimum of 8 weeks.[1] For rheumatology patients, influenza and pneumococcal vaccination with a combination of conjugated and polysaccharide vaccine is recommended.Patients treated with rituximab in the last 24 weeks are given passive immunization with tetanus globulin for high-risk injuries.[1] Patients treated with rituximab in the last 24 weeks are given passive immunization with tetanus globulin.