STAT's editorial staff shares their favorite stories from 2025 that they wish they had written themselves. Among them is the murder of UnitedHealthcare CEO Brian Thompson on a Manhattan sidewalk earlier this year. That event led many Americans to express frustration with the inequities in the health care system. More than 400 health and medical leaders gathered at the 2025 STAT Summit in Boston. They discussed how science, technology, and public trust will impact the future of medicine. Kyle, Nicole and KJ Muldoon's family experienced a scientific milestone when CRISPR was first used to correct a defect in six-month-old KJ's genes. Former CDC chief Rochelle Walensky and Daniel Jernigan talked about layoffs at the agency, the shooting at its headquarters, and the need to rebuild public health infrastructure[1][2].