Measuring the success of Sjögren's disease treatment requires more than monitoring systemic disease activity.1 Fatigue, pain, dryness, and daily function often determine patients' quality of life.1 These symptoms may not be consistent with traditional measures of the disease.1 For patients, the outcomes that matter most are those that affect their daily lives.[The success of treatment depends on early detection of the disease.[1] Even intensive and long-term therapy cannot replace damaged glands or completely eliminate mucosal dryness.[1] Treatment includes causal therapy against autoimmune inflammation and replacement therapy to replace glandular secretions.[1]