In 2025, medicine has made significant advances despite challenging conditions. Gene editing with CRISPR treats rare genetic diseases such as an enzyme mutation in an infant's liver, where lipid nanoparticles delivered the corrective instructions and dramatically improved the child's health.About half of infants with this disease die shortly after birth, while the rest survive only after a liver transplant.[1] Progress has been made in DNA diagnosis of monogenic neurological and neuromuscular diseases such as myotonic dystrophy (DM1 and DM2), where whole genome sequencing (WGS) identifies pathogenic expanded alleles with high concordance compared to conventional methods.New treatment options for aggressive pancreatic tumors, prevention of sudden cardiac death, and treatment of spinal cord injury have emerged.[2] Vaccination and prevention programs for infectious diseases, including HIV and sexually transmitted infections, have expanded.[3][4][5] For the first time in many years, the Slovak health care system has not had additional funding requirements, and construction of hospitals in Martin, Banská Bystrica, Poprad, Košice, and Bratislava is continuing.[5][6]