This is a correction by the author of the article entitled "Cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue". The article was published in Nature Medicine online on January 2, 2026 with doi:10.1038/s41591-025-04172-x. An original 2017 study shows that the cold-induced lipokine 12,13-diHOME, derived from brown adipose tissue (BAT), promotes fatty acid transport into BAT. A related analysis of plasma lipids in humans and rodents revealed a decrease in 12,13-diHOME levels with age. BAT transplantation or an increase in 12,13-diHOME in aged mice attenuated the expression of genes associated with endoplasmic reticulum (ER) and extracellular matrix stress, especially in males. 12,13-diHOME directly inhibits CaMKII, thereby regulating Ca²⁺ cycling and alleviating ER stress. These findings suggest the potential of 12,13-diHOME to protect cardiac function in aging, particularly in males.