Advanced glycation end products (AGEs) are associated with aging and skeletal muscle atrophy, where they bind to the RAGE receptor, which reduces muscle protein synthesis, increases their degradation, impairs muscle fiber regeneration, and promotes muscle cell apoptosis. This mechanism leads to the induction or worsening of muscle atrophy. The study searched the literature in PubMed, Web of Science and Embase databases using 25 search terms and included 138 relevant papers, mainly from the last 5 years. Exercise moderates the harmful effects of AGEs by reducing their formation by improving insulin sensitivity and glucose utilization, reducing chronic inflammation and oxidative stress, and increasing the kidney's ability to metabolize AGEs. These findings pave the way for drugs targeting the AGE-RAGE axis and exercise interventions against age-related sarcopenia or metabolic disorders.