A 28-year-old woman with glaucoma of the right eye since childhood had poorly controlled intraocular pressure (IOP) despite multiple surgical procedures, including two trabeculectomies and one implanted glaucoma shunt. The patient presented with skin spots of port wine on the face and blue-violet scleral pigmentation consistent with ocular melanocytosis. Examination revealed a low corneal endothelial cell count and significant optic nerve atrophy with a cup-to-disc ratio of 0.9 in the right eye. Glaucoma associated with Sturge-Weber syndrome is considered one of the most challenging types of secondary glaucoma with a low success rate of surgical interventions. The patient underwent a combined CO2 laser-assisted trabeculotomy and sclerectomy (CLASS). This procedure successfully reduced IOP below 10 mmHg without complications and preserved visual acuity.