A study examined the association between treatment of high blood pressure (antihypertensive drugs) and serious adverse events in patients of various ages and with reduced physical fitness.[1][3] The research included 185,140 patients who had not taken antihypertensive drugs, of which 42,483 were included in the detailed analysis.[1] During follow-up, 17% of patients (7,240 subjects) had at least one fall, 12.2% (5,164 subjects) at least one fracture, and 1.1% (450 subjects) had acute kidney injury.[1] A 35–50% increased risk of falls and a 4–7-fold increased risk of kidney damage were found in the first 30 days after initiation of antihypertensive therapy.[1] Treatment was associated with an increased risk of serious adverse events, with the overall absolute risk being low, except in elderly patients.[3] The study points out that the adverse effects of the treatment are mostly independent of the blood pressure reduction itself.[5]