An Australian study of 10,414,951 adults aged 25–74 (data 2011–2022) found higher cancer mortality in people with disabilities compared to those without. After age-standardization, there were 314 (95% CI: 301–328) more deaths per 100,000 person-years in disabled women (3.4% of 5,403,503 women) and 410 (95% CI: 394–427) more in men (3.7% of 5,011,448 men), with a relative risk of 1.96 times higher. The largest absolute inequalities were for lung cancer (67 for women, 103 for men per 100,000 person-years), followed by breast cancer for women (54) and colorectal cancer for both sexes (30 for women, 44 for men). Lung cancer was the main contributor to inequalities from age 35, breast cancer second in women and colorectal cancer in men. Cancers linked to smoking, obesity and alcohol accounted for much of the difference. Disability was measured as needing help with basic activities in the 2011 census, which is a major limitation. The study recommends interventions tailored to people with disabilities across the cancer control journey.