Clostridium paraputrificum is a rare species of bacteria that occurs in only 1% of all cases of clostridial infection[2][3]. This bacterium is a normal part of the intestinal flora, but when it enters the bloodstream, it can cause serious infections such as sepsis, liver abscess or joint inflammation[3]. Infection with clostridial species occurs annually in 1.8 out of 100,000 persons and has a high mortality rate ranging from 29 to 35%[1][5]. The risk of infection increases with damage to the intestinal mucosa, which can be caused by diabetes, cancer, HIV infection, alcohol consumption or other damage to the intestinal tract[3]. A case of C. paraputrificum infection without associated intestinal pathology was reported for the first time, highlighting the complexity of this rare infection[3]. Patients with this infection were usually treated with antibiotics such as meropenem and vancomycin or linezolid, with the infection clearing within 5 days[1][2].