A review examines the addition of platelet-rich plasma (PRP) to dermal fillers to alter their rheology and increase bioactivity. PRP is a biological product from the patient's own blood rich in growth factors and cytokines that support tissue regeneration and healing. The addition of PRP modulates the rheological parameters of fillers, improves biocompatibility, injectable distribution and tissue integration. This approach reduces the serious side effects of filler injections and increases their biostimulatory effects. PRP stimulates collagen formation, supports skin regeneration, extends the life of fillers and improves skin texture and elasticity. Early studies show positive results, but further clinical research is needed on the optimal dilution ratio, best practices, and long-term safety and efficacy. The combination of PRP with fillers integrates immediate volume with regenerative skin improvement.