This retrospective study investigated the relationship between blood parameters and sudden sensorineural hearing loss in 379 patients. The researchers divided the participants according to the type of audiometric configuration, time of symptom onset, and prognosis four weeks after treatment. Hemoglobin, increased neutrophil count, decreased lymphocyte count, increased monocyte count, increased platelet count, and low blood albumin were associated with a better prognosis. Conversely, an increased number of lymphocytes, age, sex, physical condition, obesity, chronic diseases including kidney disease, diabetes, hypertension, dyslipidemia and smoking were associated with a worse prognosis. The ratio of neutrophils to lymphocytes was identified as the most important independent predictive indicator, even after taking into account other inflammatory markers such as C-reactive protein and erythrocyte sedimentation rate. The study also found relationships between recovery prognosis, time of symptom onset, corticosteroid use, and degree of hearing loss. The results suggest that the combined evaluation of hematological and inflammatory markers could improve prognosis prediction and treatment approaches in sudden sensorineural hearing loss.