The study investigated how heparin protects the heart of rats after cardiac arrest with resuscitation (CA-CPR). The researchers created a cardiac arrest model in rats and divided them into three groups: a control group without intervention, a normal solution group, and a heparin group. Using proteomic analysis, they identified a total of 6,002 proteins in heart tissue, while comparing the groups without heparin and with heparin, they found 141 differentially expressed proteins (48 increased, 93 decreased). Heparin treatment significantly improved the pathological changes in cardiac tissue, including the reduction of markers of myocardial damage (CK-MB and cTnI) and the improvement of cardiac cell ultrastructure. The analysis suggested that heparin works mainly through the modulation of autophagy (natural cell cleaning) proteins IDH3A and RPTOR. The results suggest the potential of heparin as a heart-protective treatment after stroke, but the authors stress that these findings require validation in larger studies.