A cross-sectional survey at a dental school in Saudi Arabia assessed the knowledge, confidence, and preparedness of 145 dental students and interns to manage medical emergencies (response rate 72.5% of 200 invited). The majority of participants were female (51.0%) and aged ≥ 24 years (62.8%). 58.6% of respondents had a high level of knowledge, with women having slightly higher knowledge than men, but men showing higher confidence and preparedness (p = 0.05). Older and more advanced students had significantly higher knowledge and self-confidence (p < 0.05). The most common emergencies were syncope (65.5%) and seizures (29.6%). The most available emergency drug was adrenaline (38.6%), the least atropine (13.8%), while 58.6% of participants reported a lack of these drugs in outpatient clinics. The study revealed gaps in preparedness and highlighted the need for better training, regular BLS and improved access to drugs and equipment.