Maternal inflammatory biomarkers and neonatal characteristics as predictors of bronchopulmonary dysplasia in preterm infants: a retrospective cohort study

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Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2025.1735582...

Published: 2026-01-08T00:00:00Z

A study investigated whether a simple maternal blood test could predict bronchopulmonary dysplasia (BPD) - a chronic lung disease in premature babies. Researchers analyzed data from 345 mother-child pairs with preterm birth and found that 117 children (33.9%) developed BPD. Mothers of children with BPD had a lower platelet-to-white blood cell ratio (PWR), which independently predicted the onset of the disease. Other risk factors included inflammation of the amniotic sac (chorioamnionitis), male sex of the child, early sepsis, and the need for mechanical ventilation for more than 7 days. Higher gestational age and higher birth weight were protective factors. The created model achieved high accuracy (77.2% sensitivity and 80.9% specificity) and enables individual risk estimation through the nomogram. A simple maternal blood test combined with neonatal factors could help in the early identification of children at high risk of BPD and enable targeted preventive measures.