A 20-year-old woman presented to the burn center 28 days after injuring the medial parts of both thighs, which she sustained during recreational use of nitrous oxide. The injury was caused by stabilizing a container of nitrous oxide between her thighs while inflating balloons with inhalation gas. Initially, the patient noticed only redness of the skin, without providing first aid. The following day, blisters appeared on the affected areas, prompting her to visit a local medical center where her wounds were bandaged and oral clarithromycin was prescribed for suspected infection. When the condition did not improve, she was referred to a specialist burn center. On examination, patients had necrotic areas on both medial thighs. The case represents a new and increasingly common model of soft tissue injury caused by recreational use of nitrous oxide.