The article describes that the skeleton constantly renews itself throughout life and can regenerate after injury, but failure to heal fractures leads to long-term disability and higher mortality, especially in the elderly.[1] An estimated 6 to 10 million fractures occur annually in the US, with complicated healing representing a significant health problem.[1] The authors comment on a study by Xu et al. that found an unexpected role for sensory (somatosensory) nerves in bone healing.[1][2] The study mapped the neural circuits innervating the bone and observed how somatosensory neurons respond to the fracture at the level of gene expression.[2] Experimental disruption of the nerve supply led to impaired proliferation of mesenchymal cells and impaired bone cell formation, which was manifested by impaired fracture healing.[2] Analyzes at the single-cell level have identified the nerve-derived growth factor FGF9 as an important regulator of bone repair, acting through FGF9–FGFR signaling.[2] The author's commentary emphasizes that these results reveal a key communication pathway between the nervous system and the cells responsible for bone regeneration.[1][2]