Four scientists and board members recently resigned from the US National Institutes of Health (NIH). In the opinion, they say that, according to them, the NIH has lost its scientific integrity. They emphasize that they can no longer lend their personal credibility to this organization. They present their decision as a reaction to the state in which, according to them, the NIH finds itself. The text is in the form of an opinion article (opinion), not an experimental scientific study. The authors describe their departure from the NIH as a result of a loss of confidence in the institution.