Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe skin-mucosal reactions with a high risk of death for which the SCORTEN scoring system is used to estimate hospital mortality. The study retrospectively analyzed 150 adult patients (median age 50 years, 59.3% women) admitted with SJS/TEN in the Moscow cohort. The overall hospital mortality was 18.7% (28 deaths). In univariate analysis, age over 40 years, presence of malignancy, heart rate over 120/min, increased serum urea over 28 mg/dl and bicarbonate under 20 mmol/l were significantly associated with death. In multivariate Cox regression, malignancy, urea above 28 mg/dL and tachycardia remained independent predictors of death. The initial extent of epidermal detachment, serum glucose, and age did not retain prognostic significance after accounting for other factors. The authors state that the results support the continued use of SCORTEN, but point to the need for adjustments in particular renal and oncological parameters for better risk assessment in the current treatment setting.